• 西亚试剂:MicroRNA Regulation of Human Protease Genes
  • 西亚试剂:MicroRNA Regulation of Human Protease Genes
  • MicroRNA Regulation of Human Protease Genes Essential for Influenza Virus Replication Victoria A. Meliopoulos, Lauren E. Andersen, Paula Brooks, Xiuzhen Yan, Abhijeet Bakre, J. Keegan Coleman, S. Mark Tompkins, Ralph A. Tripp. Influenza A virus causes seasonal epidemics and periodic pandemics threatening the health of millions of people each year. Vaccination is an effective strategy for reducing morbidity and mortality, and in the abse...详细+
  • 西亚试剂:发现流感治疗的新靶点
  • 西亚试剂:发现流感治疗的新靶点
  • 甲型流感病毒通过季节性流行及周期性的大范围流行,正严重威胁着人类健康。一般来说,接种疫苗是降低流感发病率及致死率的有效途经,如果没有药物抗性,药物预防的疗效也比较显著。然而,药物抗性的迅速出现突出了对新的药物靶点的迫切需求。 总所周知,流感病毒的复制需要一定的宿主细胞组分。目前,对这些宿主细胞组分的研究...详细+
  • 西亚试剂:Genetic recombination is directed away from functional
  • 西亚试剂:Genetic recombination is directed away from functional
  • Genetic recombination is directed away from functional genomic elements in mice Kevin Brick, Fatima Smagulova, Pavel Khil, R. Daniel Camerini-Otero & Galina V. Petukhova Genetic recombination occurs during meiosis, the key developmental programme of gametogenesis. Recombination in mammals has been recently linked to the activity of a histone H3 methyltransferase, PR domain containing 9 (PRDM9)1, 2, 3, 4, 5, 6, the product of the only kn...详细+
  • 西亚试剂:PRDM9在同源重组中的作用
  • 西亚试剂:PRDM9在同源重组中的作用
  • 同源重组是发生在雌雄配子减数分裂过程中的重要事件,在这一过程中,来自父本和母本的同源染色体之间发生遗传物质的交换,并稳定遗传给下一代。近期研究认为,哺乳动物细胞的同源重组与一种叫做PRDM9(PR domain containing 9)的组蛋白H3甲基转移酶的活性有关。研究人员认为PRDM9能够通过其高度重复的锌指结构域结合特定DNA序列,从而使结合...详细+
  • 西亚试剂:Translational Homeostasis via the mRNA
  • 西亚试剂:Translational Homeostasis via the mRNA
  • Translational Homeostasis via the mRNA Cap-Binding Protein, eIF4E Akiko Yanagiya, Eigo Suyama, Hironori Adachi, Yuri V. Svitkin, Pedro Aza-Blanc, Hiroaki Imataka, Satoshi Mikami, Yvan Martineau, Ze'ev A. Ronai, Nahum Sonenberg Translational control of gene expression plays a key role in many biological processes. Consequently, the activity of the translation apparatus is under tight homeostatic control. eIF4E, the mRNA 5′ cap-b...详细+
  • 西亚试剂:通过泛素化途径维持翻译水平稳定
  • 西亚试剂:通过泛素化途径维持翻译水平稳定
  • 在翻译水平调节基因表达对许多生物学过程有着重要意义,因此,生物体内蛋白的翻译活性是由一套严密的机制来调控的。真核细胞翻译启动因子4F(eukaryotic translation initiation factor 4E, elF4E) 是一种帽结合蛋白,其功能是结合mRNA5'末端,与其他翻译启动因子协同作用,开始翻译过程。在帽依赖的翻译调控中,elF4E是一个关键的靶点。elF4E的活性受一...详细+
  • 西亚试剂:Mechanism of Nucleic Acid Unwinding
  • 西亚试剂:Mechanism of Nucleic Acid Unwinding
  • Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase Adeyemi O. Adedeji, Bruno Marchand, Aartjan J. W. te Velthuis, Eric J. Snijder, Susan Weiss, Robert L. Eoff, Kamalendra Singh, Stefan G. Sarafianos. The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA (dsRNA) or DNA (dsDNA) with a 5′→3′ polarity, using the energy of nucl...详细+
  • 西亚试剂:SARS病毒解旋酶NSP13的作用机制
  • 西亚试剂:SARS病毒解旋酶NSP13的作用机制
  • 近日,来自美国密苏里州立大学的研究人员阐明了SARS病毒解旋酶NSP13的作用机制。相关研究成果于5月15日在线发表在Plos ONE上。 研究发现,严重急性呼吸道综合征冠状病毒(SARS-CoV)的非结构蛋白13(NSP13)是一种解旋酶,利用能量水解核苷酸,分开双链DNA(dsRNA)或者是具有5′→3′极性的DNA(dsDNA)。 他们发现,解旋的延迟伴随着双链区域核...详细+
  • 西亚试剂:SH3 Domain Tyrosine Phosphorylation – Sites
  • 西亚试剂:SH3 Domain Tyrosine Phosphorylation – Sites
  • SH3 Domain Tyrosine Phosphorylation – Sites, Role and Evolution Zuzana Tatárová, Jan Brábek, Daniel Rsel, Marian Novotny. SH3 domains are eukaryotic protein domains that participate in a plethora of cellular processes including signal transduction, proliferation, and cellular movement. Several studies indicate that tyrosine phosphorylation could play a significant role in the regulation of SH3 domains.To explo...详细+
  • 西亚试剂:SH3结构域的络氨酸磷酸化机制
  • 西亚试剂:SH3结构域的络氨酸磷酸化机制
  • SH结构域(Src homology domain)是一种真核生物蛋白结构域,能够与受体酪氨酸激酶磷酸化残基紧密结合,从而形成多蛋白的复合物来进行信号转导。SH3结构域是最初在Src(一种癌基因)的研究中鉴定到的蛋白组件,它能够识别富含脯氨酸和疏水残基的蛋白质并与之结合,从而介导蛋白与蛋白的相互作用,SH3结构域参与了多种细胞内生化反应,包括信号转...详细+