• 西亚试剂::
  • 西亚试剂::
  • 一种能够让未成熟的精子细胞过早逃离睾丸的化合物或许为避孕药提供了新的线索。 通过关闭睾丸所独有的基因和蛋白质,那些从事“男性避孕药”研究的科学家最近发现了许多能够阻碍精子生成的方法。 如今,由美国纽约市人口理事会生物医学研究中心的C. Yan Cheng率领的一个研究小组发现了一种阻碍精子发生的新途径:破坏血液&...详细+
  • 西亚试剂::C/EBP Transcription Factors Mediate Epicardial Activation
  • 西亚试剂::C/EBP Transcription Factors Mediate Epicardial Activation
  • Guo N. Huang, Jeffrey E. Thatcher, John McAnally, Yongli Kong, Xiaoxia Qi, Wei Tan, J. Michael DiMaio, James F. Amatruda, Robert D. Gerard, Joseph A. Hill, Rhonda Bassel-Duby, Eric N. Olson The epicardium encapsulates the heart and functions as a source of multipotent progenitor cells and paracrine factors essential for cardiac development and repair. Injury of the adult heart results in reactivation of a developmental gene program in the epicardium...详细+
  • 西亚试剂::重新唤醒心脏的愈合系统
  • 西亚试剂::重新唤醒心脏的愈合系统
  • 科学家们确认了一组分子信号,这些信号可激活包围哺乳动物心脏的保护性的,及可能是修复性的组织层。这一发现可能最终会带来修复心脏损害的新策略。 该被称作心外膜的组织在发育中会提供必需的生长因子和干细胞。它在成年期会处于休眠状态,但在心脏受损时会被重新激活。这一反应重新激活了那些在发育时帮助心脏生长的基因,但...详细+
  • 西亚试剂::Zscan4 promotes genomic stability during reprogramming
  • 西亚试剂::Zscan4 promotes genomic stability during reprogramming
  • Jiang J, Lv W, Ye X, Wang L, Zhang M, Yang H, Okuka M, Zhou C, Zhang X, Liu L, Li J. Induced pluripotent stem (iPS) cells generated using Yamanaka factors have great potential for use in autologous cell therapy. However, genomic abnormalities exist in human iPS cells, and most mouse iPS cells are not fully pluripotent, as evaluated by the tetraploid complementation assay (TCA); this is most likely associated with the DNA damage response (DDR) occurr...详细+
  • 西亚试剂::保护基因组的稳定性可以显著改善iPS细胞的质量
  • 西亚试剂::保护基因组的稳定性可以显著改善iPS细胞的质量
  • 体细胞重编程技术具有重要的理论和实践意义。在再生医学研究中,通过该技术获得来自患者的多能干细胞,进一步用于自体移植可以避免免疫排斥问题,从而使其成为干细胞和再生医学研究的热点领域。 核移植和iPS技术均能将体细胞重编为多能干细胞,然而两者的重编程的能力却不同。核移植后获得的胚胎干细胞(ESCs)具有与正常ESCs相似...详细+
  • 西亚试剂::Genome-wide Methylation Profiles Reveal Quantitative
  • 西亚试剂::Genome-wide Methylation Profiles Reveal Quantitative
  • Gregory Hannum, Justin Guinney, Ling Zhao, Li Zhang,et al. The ability to measure human aging from molecular profiles has practical implications in many fields, including disease prevention and treatment, forensics, and extension of life. Although chronological age has been linked to changes in DNA methylation, the methylome has not yet been used to measure and compare human aging rates. Here, we build a quantitative model of aging using measurement...详细+
  • 西亚试剂::DNA甲基化预测机体衰老程度
  • 西亚试剂::DNA甲基化预测机体衰老程度
  • 在一项新研究中,美国加州大学圣地亚哥医学院研究人员描述了一种新的标记物,并利用新的模型在基因和分子水平来量化老化发生程度,新研究不只​​是提供一个更精确的方法来确定人的衰老程度,同时也或许提出了预见或治疗疾病的方法。该研究结果发表在11月21日的Molecular Cell杂志上。   Shiley眼科中心和基因组医学研究所主任 Kang Z...详细+
  • 西亚试剂::Three-Dimensional Architecture of the Rod Sensory
  • 西亚试剂::Three-Dimensional Architecture of the Rod Sensory
  • Jared C. Gilliam, Juan T. Chang, Ivette M. Sandoval, Youwen Zhang, Tiansen Li, Steven J. Pittler, Wah Chiu, Theodore G. Wensel   Defects in primary cilia lead to devastating disease because of their roles in sensation and developmental signaling but much is unknown about ciliary structure and mechanisms of their formation and maintenance. We used cryo-electron tomography to obtain 3D maps of the connecting cilium and adjacent cellular struc...详细+
  • 西亚试剂::开发出揭示视觉棒状感觉纤毛三维结构的新技术
  • 西亚试剂::开发出揭示视觉棒状感觉纤毛三维结构的新技术
  • 使用一种名为“电子断层扫描术”的新技术,来自贝勒医学院的研究者创建了一种三维图谱,可以帮助研究者更好地理解视觉棒状感觉纤毛由于遗传突变而引发的改变,以及帮助研究者揭示遗传突变如何影响视觉棒状感觉纤毛转运视觉感知蛋白质的过程。相关研究成果于近日刊登在了国际杂志Cell上。 在这项研究中,研究者表示,存在遗...详细+
  • 西亚试剂::The DNA Replication Factor RFC1 Is Required
  • 西亚试剂::The DNA Replication Factor RFC1 Is Required
  • Wang Y, Cheng Z, Huang J, Shi Q, Hong Y, Copenhaver GP, Gong Z, Ma H. During meiotic recombination, induced double-strand breaks (DSBs) are processed into crossovers (COs) and non-COs (NCO); the former are required for proper chromosome segregation and fertility. DNA synthesis is essential in current models of meiotic recombination pathways and includes only leading strand DNA synthesis, but few genes crucial for DNA synthesis have been tested genet...详细+