• 西亚试剂::Genome-Wide Scans for Candidate Genes
  • 西亚试剂::Genome-Wide Scans for Candidate Genes
  • Yan-Bo Sun1,3,#, Wei-Ping Zhou1,2,3,#, He-Qun Liu1,3,6, David M. Irwin1,4,5, Yong-Yi Shen1,7,* and Ya-Ping Zhang1,3,* Since their divergence from the terrestrial artiodactyls, cetaceans have fully adapted to an aquatic lifestyle, which represents one of the most dramatic transformations in mammalian evolutionary history. Numerous morphological and physiological characters of cetaceans have been acquired in response to this drastic habitat transition...详细+
  • 西亚试剂::揭示海豚水生适应的分子基础
  • 西亚试剂::揭示海豚水生适应的分子基础
  • 的方法探讨物种适应性进化的遗传基础是目前分子进化的研究热点。张亚平院士课题组针对已公布的海豚基因组,通过与其他近缘物种的基因组进行比较,系统地鉴定出海豚中经历正选择的基因及位点,为理解海豚等鲸目动物的水生适应奠定了基础,同时也为进一步研究这些基因的功能提供了线索。 鲸目动物是哺乳动物中少有的水生物种,它...详细+
  • 西亚试剂::ATP-directed capture of bioactive herbal-based
  • 西亚试剂::ATP-directed capture of bioactive herbal-based
  • Febrifugine is the active component of the Chinese herb Chang Shan (Dichroa febrifuga Lour.)1, 2, which has been used for treating malaria-induced fever for about 2,000 years. Halofuginone (HF), the halogenated derivative of febrifugine, has been tested in clinical trials for potential therapeutic applications in cancer and fibrotic disease3, 4, 5, 6. Recently, HF was reported to inhibit TH17 cell differentiation by activating the amino acid resp...详细+
  • 西亚试剂::揭开中药常山的分子作用机制
  • 西亚试剂::揭开中药常山的分子作用机制
  • 常山为虎耳草科植物常山的根,是一种传统中药,千年以来一直被人们用于治疗疟疾相关的发热。现在Scripps研究所TSRI的博后周辉皓(Huihao Zhou音译)获得了常山活性成分的高分辨率结构,揭开了常山治疗疟疾的神秘机制。 常山的活性成分被称为常山酮halofuginone,是常山碱febrifugine的衍生物,对免疫系统有部分抑制作用,不过此前人们并不了解...详细+
  • 西亚试剂::Genome-wide association study dissects
  • 西亚试剂::Genome-wide association study dissects
  • Hui Li, Zhiyu Peng, Xiaohong Yang, Weidong Wang, Junjie Fu, Jianhua Wang, Yingjia Han,Yuchao Chai, Tingting Guo, Ning Yang, Jie Liu, Marilyn L Warburton, Yanbing Cheng,Xiaomin Hao, Pan Zhang, Jinyang Zhao, Yunjun Liu, Guoying Wang, Jiansheng Li & Jianbing Yan Maize kernel oil is a valuable source of nutrition. Here we extensively examine the genetic architecture of maize oil biosynthesis in a genome-wide association study using 1.03 million SNPs cha...详细+
  • 西亚试剂::玉米籽粒油分合成关键基因破解
  • 西亚试剂::玉米籽粒油分合成关键基因破解
  • 中国农业大学教授李建生及其合作者,首次在全基因组水平上对玉米籽粒油分的遗传基础进行了深入解析。相关成果日前在线发表于《自然—遗传学》杂志。 玉米是我国第一大粮食作物。油分是玉米籽粒最重要的营养成分之一,其能量密度和价值显着高于淀粉。普通玉米中油分含量一般为4%,经过人工不断选育后的高油玉米材料油分含量可...详细+
  • 西亚试剂::Genes Contributing to Pain Sensitivity in the Normal
  • 西亚试剂::Genes Contributing to Pain Sensitivity in the Normal
  • Frances M. K. Williams, Serena Scollen, Dandan Cao, Yasin Memari, Craig L. Hyde, Baohong Zhang, Benjamin Sidders, Daniel Ziemek, Yujian Shi, Juliette Harris, Ian Harrow, Brian Dougherty, Anders Malarstig, Robert McEwen, Joel C. Stephens, Ketan Patel, Cristina Menni, So-Youn Shin, Dylan Hodgkiss, Gabriela Surdulescu, Wen He, Xin Jin, Stephen B. McMahon, Nicole Soranzo, Sally John, Jun Wang, Tim D. Spector. Sensitivity to pain varies considerably betw...详细+
  • 西亚试剂::研究发现个体疼痛敏感性的遗传差异
  • 西亚试剂::研究发现个体疼痛敏感性的遗传差异
  • 主要作者Frances Williams博士说:慢性疼痛是一种重要的个人和社会经济负担,有近五分之一的人在某一段时间内会经历慢性疼痛。 目前,疼痛治疗往往疗效有限或存在副作用,对许多人来说,一种新的方法来缓解疼痛可能性是一个令人兴奋的科技成果。据了解,那些日常生活中对疼痛最敏感的人更容易发展为慢性疼痛。 为了识别人对疼痛的...详细+
  • 西亚试剂::Loaded Dice for Human Genome Mutation
  • 西亚试剂::Loaded Dice for Human Genome Mutation
  • Chris P. Ponting Not all bases in the human genome are equally prone to chance mutations. Michaelson et al. show that individuals can acquire clusters of de novo DNA changes and propose that the likelihood of single base pair change differs across three orders of magnitude. 丙烯醛肉桂醛桂皮醛4-硝基肉桂醛...详细+
  • 西亚试剂::人类基因突变“冷热不均”
  • 西亚试剂::人类基因突变“冷热不均”
  • 人类基因组中并不是所有的碱基都容易发生突变,基因组也会出现“冷热不均”的现象,近期一研究组发现了获取DNA新生突变集群的方法,并指出这种单碱基对变化出现的可能性相差了三个数量级。牛津大学的Chris P. Ponting对此进行了深入评点。 父母生殖细胞形成时所发生的胚系de novo突变(germline de novo mutation,DNM)在人类疾病中发挥着...详细+