• 西亚试剂:线粒体融合过程新机制
  • 西亚试剂:线粒体融合过程新机制
  • 来自中科院生物膜与膜生物工程国家重点实验室,南开大学,北京大学等处的研究人员发现了线粒体融合过程中的一种新机制,这对于深入解析线粒体融合,以及相关的,神经退行性疾病等具有重要意义。这一研究成果公布在Nature Communications上。 这一文章的通讯作者是中国科学院陈佺研究员,其早年毕业于湖北大学,目前的研究方向是分析线...详细+
  • 西亚试剂:De Novo Designed Proteins from a Library of Artificial Sequ
  • 西亚试剂:De Novo Designed Proteins from a Library of Artificial Sequ
  • De Novo Designed Proteins from a Library of Artificial Sequences Function in Escherichia Coli and Enable Cell Growth Mark Isalan, Michael A. Fisher, Kara L. McKinley, Luke H. Bradley, Sara R. Viola, Michael H. Hecht. Abstract A central challenge of synthetic biology is to enable the growth of living systems using parts that are not derived from nature, but designed and synthesized in the laboratory. As an initial step toward achieving this g...详细+
  • 西亚试剂:miR-499 regulates mitochondrial dynamics by targeting calci
  • 西亚试剂:miR-499 regulates mitochondrial dynamics by targeting calci
  • miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1 Jian-Xun Wang,Jian-Qin Jiao,Qian Li,Bo Long,Kun Wang,Jin-Ping Liu,Yan-Rui Li& Pei-Feng Li Myocardial infarction is a leading cause of mortality worldwide. Here we report that modulation of microRNA-499 (miR-499) levels affects apoptosis and the severity of myocardial infarction and cardiac dysfunction induced by ischemia-reperfusion. We found that bot...详细+
  • 西亚试剂:miR-499对条件诱导的心肌梗塞及心肌细胞凋亡的影响
  • 西亚试剂:miR-499对条件诱导的心肌梗塞及心肌细胞凋亡的影响
  • 近日中科院动物研究所生物膜与膜生物工程国家重点实验室的研究人员在研究中检测了一种miRNA: miR-499对于条件诱导的心肌梗塞严重程度及心肌细胞凋亡的影响,并揭示了miR-499在心肌细胞中的调控机制。这将对心脏疾病的预防、治疗以及生物医药产业的发展起到重要推动作用。这一研究成果发表在国际著名杂志 Nature medicine 上。 领导这一研究...详细+
  • 西亚试剂:H3K36 methylation antagonizes PRC2 mediated H3K27 methylati
  • 西亚试剂:H3K36 methylation antagonizes PRC2 mediated H3K27 methylati
  • H3K36 methylation antagonizes PRC2 mediated H3K27 methylation Wen Yuan1, Mo Xu2, Chang Huang1, Nan Liu3, She Chen4 and Bing Zhu4,* Abstract H3K27 methylation mediated by the histone methyltransferase complex PRC2 is critical for transcriptional regulation, Polycomb silencing, Drosophila segmentation, mammalian X chromosome inactivation and cancer. PRC2-mediated H3K27 methylation can spread along the chromatin and propagate the repressive chr...详细+
  • 西亚试剂:上海巴斯德所肿瘤疱疹病毒周期调控研究获得进展
  • 西亚试剂:上海巴斯德所肿瘤疱疹病毒周期调控研究获得进展
  • 国际学术杂志 PLoS ONE 在线发表了上海巴斯德研究所蓝柯研究组关于肿瘤疱疹病毒--卡波济肉瘤病毒(Kaposi’s Sarcoma associated herpesvirus,KSHV)周期调控研究的最新成果。该研究通过利用不同于之前的实验系统,验证了其他研究组报导的miR-K12-9能够下调RTA的表达。该研究还报导了一个新的KSHV编码能够通过直接抑制裂解期主要调控基因RTA,并影响RT...详细+
  • 西亚试剂:Structural basis for site-specific ribose methylation by bo
  • 西亚试剂:Structural basis for site-specific ribose methylation by bo
  • Structural basis for site-specific ribose methylation by box C/D RNA protein complexes Jinzhong Lin,Shaomei Lai,Ru Jia,Anbi Xu,Liman Zhang,Jing Lu& Keqiong Ye Box C/D RNA protein complexes (RNPs) direct site-specific 2′-O-methylation of RNA and ribosome assembly1, 2, 3, 4. The guide RNA in C/D RNP forms base pairs with complementary substrates and selects the modification site using a molecular ruler5, 6, 7. Despite many studies of C/D RNP...详细+
  • 西亚试剂:C/D RNA蛋白质复合物催化RNA核糖甲基化的结构机理
  • 西亚试剂:C/D RNA蛋白质复合物催化RNA核糖甲基化的结构机理
  • 北京生命科学研究所叶克穷实验室在《自然》杂志发表论文,该论文研究了C/D RNA蛋白质复合物催化RNA核糖甲基化的结构机理。 C/D RNA是普遍存在于真核生物和古细菌的一类古老的非编码RNA,它们主要介导核糖体RNA和剪切体RNA大量特定位点上的核糖甲基化修饰,同时参与真核生物核糖体的装配。在古细菌中,C/D RNA和甲基转移酶fibrillarin,RNA结合...详细+
  • 西亚试剂:DNA磷硫酰化修饰在细菌基因组中广泛分布且量化存在
  • 西亚试剂:DNA磷硫酰化修饰在细菌基因组中广泛分布且量化存在
  • 日前,美国科学院院刊(PNAS)发表了上海交通大学、武汉大学与美国麻省理工学院共同合作,以王连荣教授为第一作者、陈实教授和彼得·帝丹教授为共同通讯作者的一篇论文:“DNA磷硫酰化修饰在细菌基因组中广泛分布且量化存在”。这是DNA骨架上硫修饰研究领域又一个新的重大进展,也是邓子新院士团队与彼得·帝丹教授合作...详细+
  • 西亚试剂:Break-Induced Replication Is Highly Inaccurate
  • 西亚试剂:Break-Induced Replication Is Highly Inaccurate
  • Break-Induced Replication Is Highly Inaccurate Angela Deem1, Andrea Keszthelyi2, Tiffany Blackgrove1, Alexandra Vayl1, Barbara Coffey1, Ruchi Mathur1, Andrei Chabes2,3, Anna Malkova1* Abstract DNA must be synthesized for purposes of genome duplication and DNA repair. While the former is a highly accurate process, short-patch synthesis associated with repair of DNA damage is often error-prone. Break-induced replication (BIR) is a unique cellu...详细+