中文名称:乙二醇双(2-氨基乙基醚)四乙酸
中文同义词:乙二醇双(氨乙基醚)四乙酸;乙二醇双(2-氨基乙基醚)四乙;乙二醇-O,O'-双(2-氨乙基)-N,N,N',N'-四乙酸;乙二醇双醚四乙酸;乙二醇双(2-氨基乙基醚)-N,N,N',N'-四乙酸;乙二醇-O,O'-二(3-氨乙基)-N,N,N',N'-四乙酸,97%;乙二醇二乙醚二胺四乙酸;乙二醇双（2-氨基乙基醚）四乙酸（EGTA）
英文名称:Ethylenebis(oxyethylenenitrilo)tetraaceticacid
英文同义词:3,6-DIOXAOCTAMETHYLENEDINITRILOTETRAACETICACID;1,2-bis(2-dicarboxymethylaminoethoxy)ethane;12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-9-dioxa-3;6,9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-;9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-6;ebonta;ethylenedioxybis(ethyleneamino)tetraaceticacid;ETHYLENEGLYCOLBIS-(BETA-AMINOETHYLETHER)-N,N,N',N'-TETRAACETIC
CAS号:67-42-5
分子式:C14H24N2O10
分子量:380.35
EINECS号:200-651-2
乙二醇双(2-氨基乙基醚)四乙酸性质
熔点241°C(dec.)(lit.)
沸点507.99°C(roughestimate)
密度1.2838(roughestimate)
折射率1.4590(estimate)
储存条件StoreatRT.
溶解度0.1MNaOH:0.1Mat20°C,clear,colorless
酸度系数(pKa)1.47±0.10(Predicted)
形态CrystallinePowder
颜色White
水溶解性slightlysoluble
Merck14,3529
BRN1717370
生物活性
EGTA 是一种特殊的钙离子螯合剂。EGTA 在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。
体外研究
EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC 50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules.
