化学性质
属性
密度
1.2600
溶解性
Soluble in water (partly), ethanol (4%), methanol (4%), DMF, and DMSO.
存贮条件
储存温度-20°C
描述
产品介绍
Ostreogrycin A, also known as Virginiamycin M1, is a streptogramin macrolide antibiotic. Ostreogrycin A interacts with the bacterial 50S ribosome, inhibiting its function in a reversible manner. Activity of Ostreogrycin A at the ribosome blocks translation and produces a bacteriostatic effect. With addition of Virginiamycin S1 , the two antibiotics produce a synergistic bacteriocidal effect. The combination of these compounds, available as a Virginimycin complex , demonstrate efficacy against a broad range of bacteria.
别名
春霉素 A;Mikamycin A;Staphylomycin
生化机理
Virginiamycin M1 inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. It inactivates the 50S ribosome. S. virginiae inactivates VM1 by reducing its 16-carbonyl group, forming 16R-dihydroVM1. VM1 reductase participates solely in VM1 inactivation in vivo
应用
A bacteriostatic inhibitor of translation at the 50S ribosome
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密度 ：1.26 g/cm³
沸点 ：825.2ºC at 760 mmHg
分子式 ：C28H35N₃O7
分子量 ：525.59300
闪点 ：452.9ºC
精确质量 ：525.24800
PSA ：139.04000
LogP ：2.92610
蒸汽压 ：0mmHg at 25℃
折射率 ：1.586
危险属性
个人防护设备
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
WGK德国
3
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个人防护装备 ： Eyeshields; Gloves; type N95 (US); type P1 (EN143) respirator filter
危险品运输编码 ：NONH for all modes of transport
