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无活菌素来源于灰色链霉菌变种

别名:铵离子载体 产品编号:272368 CAS号:6833-84-7 分子式:C40H64O12 分子量:736.93(forNonactin)

订货信息

订货编号 产品名称 规格 包装 价格 数量 操作
A60863-5mg 无活菌素来源于灰色链霉菌变种 ≥96.0% 5mg 425.00

A60863-25mg 无活菌素来源于灰色链霉菌变种 ≥96.0% 25mg 1144.00

A60863-100mg 无活菌素来源于灰色链霉菌变种 ≥96.0% 100mg 4464.00

化学性质


属性





敏感性


对湿度敏感




熔点


145℃ - 146℃




溶解性


Soluble in chloroform (9.80 - 10.20 mg/ml), ethanol (10 mM), DMSO (10 mg/ml), and methanol. Insoluble in water.




存贮条件


储存温度-20°C,充氩储存





描述





产品介绍


Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin.Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request




别名


铵离子载体;Ammonium Ionophore;Werramycin-A;Polynactin




生化机理


Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation




应用


Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN.Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.Nonactin is used in urea and ammonium specific electrodes.



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密度 :1.041 g/cm³

沸点 :890.6ºC at 760 mmHg

分子式 :C40H64O12

分子量 :736.92900

闪点 :352.7ºC

精确质量 :736.44000

PSA :142.12000

LogP :6.02200

折射率 :1.452

计算化学 :

1.疏水参数计算参考值(XlogP):6.6

2.氢键供体数量:0

3.氢键受体数量:12

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积142

7.重原子数量:52

8.表面电荷:0

9.复杂度:1040

10.同位素原子数量:0

11.确定原子立构中心数量:16

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1


危险属性





个人防护设备


Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter




WGK德国


3



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个人防护装备 : Eyeshields; Gloves; type N95 (US); type P1 (EN143) respirator filter

危害码 (欧洲) :Xi

安全声明 (欧洲) :S22-S24/25

危险品运输编码 :NONH for all modes of transport

RTECS号 :RH1685000

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