化学性质
属性
敏感性
对湿度敏感
熔点
145℃ - 146℃
溶解性
Soluble in chloroform (9.80 - 10.20 mg/ml), ethanol (10 mM), DMSO (10 mg/ml), and methanol. Insoluble in water.
存贮条件
储存温度-20°C,充氩储存
描述
产品介绍
Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin.Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request
别名
铵离子载体;Ammonium Ionophore;Werramycin-A;Polynactin
生化机理
Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation
应用
Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN.Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.Nonactin is used in urea and ammonium specific electrodes.
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密度 :1.041 g/cm³
沸点 :890.6ºC at 760 mmHg
分子式 :C40H64O12
分子量 :736.92900
闪点 :352.7ºC
精确质量 :736.44000
PSA :142.12000
LogP :6.02200
折射率 :1.452
计算化学 :
1.疏水参数计算参考值(XlogP):6.6
2.氢键供体数量:0
3.氢键受体数量:12
4.可旋转化学键数量:0
5.互变异构体数量:无
6.拓扑分子极性表面积142
7.重原子数量:52
8.表面电荷:0
9.复杂度:1040
10.同位素原子数量:0
11.确定原子立构中心数量:16
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
危险属性
个人防护设备
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国
3
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个人防护装备 : Eyeshields; Gloves; type N95 (US); type P1 (EN143) respirator filter
危害码 (欧洲) :Xi
安全声明 (欧洲) :S22-S24/25
危险品运输编码 :NONH for all modes of transport
RTECS号 :RH1685000