化学性质
Zeocinisanantibioticinthebleomycinfamily.ItsmodeofactionistointercalateintotheDNAanddegradeit.TheZeocinresistancegeneencodesa13,665daltonprotein.ThisproteinconfersresistancetoZeocinbybindingtotheantibioticandpreventingitfrombindingDNA.Zeociniseffectiveonmostaerobiccellsandcanbeusedforselectioninmammaliancelllines,yeast,andbacteria.ForZeocintobeactive,thesaltconcentrationintheselectionmediamustbelessthan90mMNaCl.TheamountofZeocinrequiredforselectionwillvarywitheachcelltype.Contents&Storage