西亚试剂：Pluripotent reprogramming of fibroblasts by lentiviral-medi

Pluripotent reprogramming of fibroblasts by lentiviral-mediated insertion of SOX2, C-MYC and TCL-1A.
Virginia Pican?o-Castro, Elisa Maria Souza Russo-Carbolante, Luiza Junqueira Reis, Ana Maria Fraga, Danielle Aparecida Rosa de Magalh?es, Maristela Delgado Orellana, Rodrigo Alexandre Panepucci, Lygia Veiga Pereira, Dimas Tadeu Covas.

Reprogramming of somatic cells to pluripotency, promises to boost cellular therapy. Most instances of direct reprogramming have been achieved by forced expression of defined exogenous factors using multiple viral vectors. The most used four transcription factors, OCT4, SOX2, KLF4 and C-MYC, can induce pluripotency in mouse and human fibroblasts. Here we report that forced expression of a new combination of transcription factors (TCL-1A, C-MYC and SOX2) is sufficient to promote the reprogramming of human fibroblast into pluripotent cells. These three-factor pluripotent cells are similar to human embryonic stem cells (hESC) in morphology, in the ability to differentiate into cells of the three embryonic layers, and at the level of global gene expression. Induced pluripotent human cells generated by combination of other factors will be of great help for the understanding of reprogramming pathways. This in turn will allow us to better control cell-fate and apply this knowledge to cell therapy.

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