西亚试剂：Lung function and airway diseases

Lung function and airway diseases
Scott T Weiss

Scott T. Weiss is at Harvard Medical School, Center for Genomic Medicine, and the Channing Laboratory, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

Two studies report genome-wide association studies for lung function, using cross-sectional spirometric measurements in healthy individuals. They identify six genetic loci newly associated to natural variation in lung function, which may have implications for the related airway diseases of asthma and chronic obstructive pulmonary disease.

Asthma is a clinical syndrome defined by spontaneous or chemically induced increased airway responsiveness (bronchoconstriction) and reversible airflow obstruction (bronchodilation) with airway inflammation, often allergic in nature. In contrast, chronic obstructive pulmonary disease (COPD) is an airway disease with inflammation, but here the source of the inflammation is usually cigarette smoking, and it is defined by fixed, rather than reversible, airflow obstruction1.

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