西亚试剂：MiR-150 Controls B Cell Differentiation by Targeting the Tr

MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb

Changchun Xiao,1 Dinis Pedro Calado,1,4 Gunther Galler,1,4 To-Ha Thai,1 Heide Christine Patterson,1 Jing Wang,1 Nikolaus Rajewsky,2,5 Timothy P. Bender,3 and Klaus Rajewsky1,

1 The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
2 Center for Comparative Functional Genomics, Department of Biology, New York University, New York, NY 10003, USA
3 Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA

Corresponding author
Klaus Rajewsky
MiR-150 is a microRNA (miRNA) specifically expressed in mature lymphocytes, but not their progenitors. A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development. Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response. Our results identify a key transcription factor as a critical target of a stage-specifically expressed miRNA in lymphocytes and suggest that this and perhaps other miRNAs have evolved to control the expression of just a few critical target proteins in particular cellular contexts.

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