西亚试剂：Simultaneous generation and germline transmission of multip

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems

Wei Li，  Fei Teng，  Tianda Li  & Qi Zhou

CRISPRs are clustered， regularly interspaced， short palindromic repeats present in many bacteria and archaea genomes. Proteins encoded by CRISPR-associated (Cas) genes serve as guardians of the genome， which target foreign DNA at specific sites by means of small CRISPR RNA (crRNA)-guided DNA recognition and degradation1， 2， 3， 4.…

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