西亚试剂：Generation of tumor-targeted human T lymphocytes from induc

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy

Maria Themeli，  Christopher C Kloss，  Giovanni Ciriello，  Victor D Fedorov，  Fabiana Perna， Mithat Gonen  & Michel Sadelain

Progress in adoptive T-cell therapy for cancer and infectious diseases1， 2 is hampered by the lack of readily available， antigen-specific， human T lymphocytes. Pluripotent stem cells could provide an unlimited source of T lymphocytes， but the therapeutic potential of human pluripotent stem cell–derived lymphoid cells generated to date remains uncertain3， 4， 5， 6. Here we combine induced pluripotent stem cell (iPSC)7 and chimeric antigen receptor (CAR)8 technologies to generate human T cells targeted to CD19， an antigen expressed by malignant B cells， in tissue culture. These ipsC-derived， CAR-expressing T cells display a phenotype resembling that of innate γδ T cells. Similar to CAR-transduced， peripheral blood γδ T cells， the ipsC–derived T cells potently inhibit tumor growth in a xenograft model. This approach of generating therapeutic human T cells 'in the dish' may be useful for cancer immunotherapy and other medical applications.

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