西亚试剂：GATA-3 regulates the self-renewal of long-term hematopoieti

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

Catherine Frelin，  Robert Herrington，  Salima Janmohamed，  Mary Barbara，  Gary Tran， Christopher J Paige，  Patricia Benveniste，  Juan-Carlos Zuiga-Pflücker，  Abdallah Souabni， Meinrad Busslinger  & Norman N Iscove

The transcription factor GATA-3 is expressed and required for differentiation and function throughout the T lymphocyte lineage. Despite evidence it may also be expressed in multipotent hematopoietic stem cells (HSCs)， any role for GATA-3 in these cells has remained unclear. Here we found GATA-3 was in the cytoplasm in quiescent long-term stem cells from steady-state bone marrow but relocated to the nucleus when HSCs cycled. Relocation depended on signaling via the mitogen-activated protein kinase p38 and was associated with a diminished capacity for long-term reconstitution after transfer into irradiated mice. Deletion of Gata3 enhanced the repopulating capacity and augmented the self-renewal of long-term HSCs in cell-autonomous fashion without affecting the cell cycle. Our observations position GATA-3 as a regulator of the balance between self-renewal and differentiation in HSCs that acts downstream of the p38 signaling pathway.

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