西亚试剂：Actin, Spectrin, and Associated Proteins Form a Periodic Cy

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

Ke Xu1,*, Guisheng Zhong1,*, Xiaowei Zhuang1,2,†

Actin and spectrin play important roles in neurons, but their organization in axons and dendrites remains unclear. We used stochastic optical reconstruction microscopy to study the organization of actin, spectrin, and associated proteins in neurons. Actin formed ring-like structures that wrapped around the circumference of axons and evenly spaced along axonal shafts with a periodicity of ~180 to 190 nm. This periodic structure was not observed in dendrites, which instead contained long actin filaments running along dendritic shafts. Adducin, an actin-capping protein, colocalized with the actin rings. Spectrin exhibited periodic structures alternating with those of actin and adducin, and the distance between adjacent actin-adducin rings was comparable to the length of a spectrin tetramer. Sodium channels in axons were distributed in a periodic pattern coordinated with the underlying actin-spectrin–based cytoskeleton.

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