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西亚试剂优势供应上万种化学试剂产品，欢迎各位新老客户咨询、选购！
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P-CRESIDINE
| Flammability | 1 | |
| Toxicity | 2 | |
| Body Contact | 2 | |
| Reactivity | 1 | |
| Chronic | 3 | |
| SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 | ||
Intermediate in the production of azo- dyes. Residual impurities of p- cresidine may be
present in some dyes.
C8-H11-N-O, C8-H11-N-O, CH3C6H3(OCH3)NH2, "o-anisidine, 5-methyl-", "o-anisidine, 5-
methyl-", "m-amino-p-cresol, methyl ester", "m-amino-p-cresol, methyl ester", "3-amino-
p-cresol, methyl ester", "3-amino-p-cresol, methyl ester", 3-amino-4-methoxytoluene, 3-
amino-4-methoxytoluene, 2-amino-4-methylanisole, 2-amino-4-methylanisole, "benzenamine,
2-methoxy-5-methyl-", "benzenamine, 2-methoxy-5-methyl-", cresidine, 2-methoxy-5-
methylaniline, 2-methoxy-5-methylaniline, 2-methoxy-5-methylbenzenamine, 2-methoxy-5-
methylbenzenamine, 4-methoxy-m-toluidine, 4-methoxy-m-toluidine, 4-methyl-2-aminoanisole,
4-methyl-2-aminoanisole, 5-methyl-o-anisidine, 5-methyl-o-anisidine
Harmful if swallowed.
May cause CANCER.
Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. The substance and/or its metabolites may bind to hemoglobin inhibiting normal uptake of oxygen. This condition, known as "methemoglobinemia", is a form of oxygen starvation (anoxia). Symptoms include cyanosis (a bluish discoloration skin and mucous membranes) and breathing difficulties. Symptoms may not be evident until several hours after exposure. At about 15% concentration of blood methemoglobin there is observable cyanosis of the lips, nose and earlobes. Symptoms may be absent although euphoria, flushed face and headache are commonly experienced. At 25-40%, cyanosis is marked but little disability occurs other than that produced on physical exertion. At 40-60%, symptoms include weakness, dizziness, lightheadedness, increasingly severe headache, ataxia, rapid shallow respiration, drowsiness, nausea, vomiting, confusion, lethargy and stupor. Above 60% symptoms include dyspnea, respiratory depression, tachycardia or bradycardia, and convulsions. Levels exceeding 70% may be fatal.
Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.
Skin contact is not thought to produce harmful health effects (as classified using animal models). Systemic harm, however, has been identified following exposure of animals by at least one other route and the material may still produce health damage following entry through wounds, lesions or abrasions. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Open cuts, abraded or irritated skin should not be exposed to this material. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
There is ample evidence that this material can be regarded as being able to cause cancer in humans based on experiments and other information. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Most arylamines are powerful poisons to the blood-making system. High chronic doses cause congestion of the spleen and tumor formation. When administered in the diet, p-cresidine increased the incidence of squamous cell and transitional cell carcinomas of the urinary bladder and olfactory neoblastomas in rats of both sexes and neoplastic liver nodules in male rats. When administered to the diet of mice the incidence of carcinomas of the urinary bladder in both sexes, and hepatocellular carcinomas in female mice.
