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N-HEXANOL
| Flammability | 1 | |
| Toxicity | 2 | |
| Body Contact | 2 | |
| Reactivity | 1 | |
| Chronic | 0 | |
| SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 | ||
Used in pharmaceuticals (introduction of hexyl group into hypnotics, antiseptics, perfume
esters, etc.), solvent plasticzer, intermediate for textile and leather finishing agents.
CH3(CH2)42CH2OH, C6-H14-O, l-hexanol, l-hexanol, "hexyl alcohol", "n-hexyl alcohol", "n-
hexyl alcohol", amylcarbinol, "caproyl alcohol", "hexanol normal", l-hydroxyhexane, l-
hydroxyhexane, pentylcarbinol, "Epal 6", "normal hexanol", hexan-1-ol, hexan-1-ol
Harmful if swallowed.
Irritating to eyes.
HARMFUL - May cause lung damage if swallowed.
Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. Swallowing of the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis; serious consequences may result. (ICSC13733). Overexposure to non-ring alcohols causes nervous system symptoms. These include headache, muscle weakness and inco-ordination, giddiness, confusion, delirium and coma. Digestive symptoms may include nausea, vomiting and diarrhea. Aspiration is much more dangerous than ingestion because lung damage can occur and the substance is absorbed into the body. Alcohols with ring structures and secondary and tertiary alcohols cause more severe symptoms, as do heavier alcohols.
There is evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Severe inflammation may be expected with pain. There may be damage to the cornea. Unless treatment is prompt and adequate there may be permanent loss of vision. Conjunctivitis can occur following repeated exposure.
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Most liquid alcohols appear to act as primary skin irritants in humans. Significant percutaneous absorption occurs in rabbits but not apparently in man. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. The liquid may be miscible with fats or oils and may degrease the skin, producing a skin reaction described as non-allergic contact dermatitis. The material is unlikely to produce an irritant dermatitis as described in EC Directives .
If exposure to highly concentrated solvent atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and possible death. Aliphatic alcohols with more than 3-carbons cause headache, dizziness, drowsiness, muscle weakness and delirium, central depression, coma, seizures and behavioral changes. Secondary respiratory depression and failure, as well as low blood pressure and irregular heart rhythms, may follow. Nausea and vomiting are seen, and liver and kidney damage is possible as well following massive exposures. Symptoms are more acute the more carbons there are in the alcohol. The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.
Long-term exposure to the product is not thought to produce chronic effects adverse to the health (as classified using animal models); nevertheless exposure by all routes should be minimized as a matter of course.
