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西亚试剂优势供应上万种化学试剂产品，欢迎各位新老客户咨询、选购！
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西亚试剂 —— 品质可靠，值得信赖
O-CHLOROPHENOL
| Flammability | 1 | |
| Toxicity | 2 | |
| Body Contact | 2 | |
| Reactivity | 1 | |
| Chronic | 2 | |
| SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 | ||
Used in organic synthesis (dyes); as solvent in the determination of I.V.' s.
C6-H5-Cl-O, ClC6H4-OH, 2-chloro-1-hydroxybenzene, 2-chloro-1-hydroxybenzene, 2-
hydroxychlorobenzene, 2-hydroxychlorobenzene, "chloro-2 phenol", 1-chloro-2-
hydroxybenzene, 1-chloro-2-hydroxybenzene, "phenol, o-chloro-", "phenol, o-chloro-",
orthochlorophenol, chlorophenol
Harmful by inhalation, in contact with skin and if swallowed.
May cause long- term adverse effects in the environment.
Toxic to aquatic organisms, may cause long- term adverse effects in the aquatic
environment.
Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. Some phenol derivatives can cause damage to the digestive system. If absorbed, profuse sweating, thirst, nausea, vomiting diarrhea, cyanosis, restlessness, stupor, low blood pressure, gasping, abdominal pain, anemia, convulsions, coma and lung swelling can happen followed by pneumonia. There may be respiratory failure and kidney damage. Chemical burns, seizures and irregular heartbeat may result.
There is some evidence to suggest that this material can causeeye irritation and damage in some persons. Some phenol derivatives may produce mild to severe eye irritation with redness, pain and blurred vision. Permanent eye injury may occur; recovery may also be complete or partial.
Skin contact with the material may be harmful; systemic effects may resultfollowing absorption. There is some evidence to suggest that this material can cause inflammation of the skin on contact in some persons. Phenol and its derivatives can cause severe skin irritation if contact is maintained, and can be absorbed to the skin affecting the cardiovascular and central nervous system. Effects include sweating, intense thirst, nausea and vomiting, diarrhea, cyanosis, restlessness, stupor, low blood pressure, hyperventilation, abdominal pain, anemia, convulsions, coma, lung swelling followed by pneumonia. Respiratory failure and kidney damage may follow. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. Exposure to the material may result in a skin inflammation called chloracne. This is characterized by white- and blackheads, keratin cysts, spots, excessive discoloration. These mainly involve the skin under the eyes and behind the ears. The reaction may be delayed. There may also be excess hair growth, degeneration of elastic tissue as a result of sunlight, and scarring of the membrane of the penis. Chlorinated diphenyl ethers may produced skin irritation; systemic toxicitymay occur following absorption.
Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful. There is some evidence to suggest that the material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. If phenols are absorbed via the lungs, systemic effects may occur affecting the cardiovascular and nervous systems. Inhalation can result in profuse perspiration, intense thirst, nausea, vomiting, diarrhea, cyanosis, restlessness, stupor, falling blood pressure, hyperventilation, abdominal pain, anemia, convulsions, coma, swelling and inflammation of the lung. This is followed by respiratory failure and kidney damage. Phenols also cause loss of sensation and general depression at high concentrations. The toxicities of phenol derivatives vary.
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment. Long-term exposure to phenol derivatives can cause skin inflammation, loss of appetite and weight, weakness, muscle aches and pain, liver damage, dark urine, loss of nails, skin eruptions, diarrhea, nervous disorders with headache, salivation, fainting, discoloration of the skin and eyes, vertigo and mental disorders, and damage to the liver and kidneys. Chlorphenols have been associated with cancers of the throat, noseand connective tissue. Prolonged contact with chlorinated diphenyl ethers may cause skin irritation, weight loss and liver injury. Repeated absorption has produced liver damage in animals. Chlorinated diphenyl ethers (PCDEs) are by-products in the manufacture of chlorinated phenols.
