• 西亚试剂:膜蛋白形成瞬间被成功拍摄
  • 西亚试剂:膜蛋白形成瞬间被成功拍摄
  • 在两项最新的研究中,研究人员首次详细地描述了生产蛋白质的核糖体如何将刚形成的蛋白质嵌入到细胞膜内,并首次获得蛋白质进入膜的图片。 第一项研究发表在《自然结构和分子生物学》杂志上。美国伊利诺伊大学的理论与计算化学科学家同德国慕尼黑大学的研究人员通力合作,利用低温电子显微镜研究了核糖体、细胞膜、膜通道及...详细+
  • 西亚试剂:Substrate-modulated gating dynamics in a Na+-coupled neurot
  • 西亚试剂:Substrate-modulated gating dynamics in a Na+-coupled neurot
  • Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue Yongfang Zhao,1, 2, 4, 7 Daniel S. Terry,5, 7 Lei Shi,5, 6, 7 Matthias Quick,1, 2, 4 Harel Weinstein,5, 6 Scott C. Blanchard5 & Jonathan A. Javitch1, 2, 3, 4 Neurotransmitter/Na+ symporters (NSSs) terminate neuronal signalling by recapturing neurotransmitter released into the synapse in a co-transport (symport) mechanism driven by the Na+ electrochemical ...详细+
  • 西亚试剂:神经元转运蛋白分子运动机制
  • 西亚试剂:神经元转运蛋白分子运动机制
  • 神经元细胞拥有不同的转运蛋白,但这些转运蛋白如何工作迄今还是一个谜。据美国物理学家组织网4月24日报道,美国科学家最近终于弄清楚了转运蛋白分子的工作机制,研究发表在24日出版的《自然》杂志上。科学家表示,新研究有望改进对精神疾病治疗的效果,加深理解可卡因等神经药物的作用原理。 转运蛋白是内嵌于神经元细胞膜内的...详细+
  • 西亚试剂:A system for the continuous directed evolution of biomolecu
  • 西亚试剂:A system for the continuous directed evolution of biomolecu
  • A system for the continuous directed evolution of biomolecules Kevin M. Esvelt,1 Jacob C. Carlson2 & David R. Liu2, 3 Laboratory evolution has generated many biomolecules with desired properties, but a single round of mutation, gene expression, screening or selection, and replication typically requires days or longer with frequent human intervention1. Because evolutionary success is dependent on the total number of rounds performed2, a means of ...详细+
  • 西亚试剂:噬菌体辅助持续进化(PACE)方法让生物分子进化增速100倍
  • 西亚试剂:噬菌体辅助持续进化(PACE)方法让生物分子进化增速100倍
  • 美国科学家在《自然》杂志上撰文指出,他们利用噬菌体,在实验室中让生物分子的进化速度提高了100倍。新研究有望让业使用实验室培育出来的蛋白质、核酸和其他成分按需制药。 噬菌体辅助持续进化(PACE) 该研究的领导者、哈佛大学化学和生化教授戴维·刘说,大多数现代药物都由有机小分子制成,但某些情况下,蛋白质或核...详细+
  • 西亚试剂:SecB-like chaperone controls a toxin–antitoxin stress-respo
  • 西亚试剂:SecB-like chaperone controls a toxin–antitoxin stress-respo
  • SecB-like chaperone controls a toxin–antitoxin stress-responsive system in Mycobacterium tuberculosis Patricia Bordes, Anne-Marie Cirinesi, Roy Ummels, Ambre Sala, Samer Sakr, Wilbert Bitter, and Pierre Genevaux Edited by Linda L. Randall, University of Missouri, Columbia, MO, and approved April 12, 2011 (received for review January 22, 2011) [Abstract] A major step in the biogenesis of newly synthesized precursor proteins in bacte...详细+
  • 西亚试剂:Measuring the evolutionary rate of protein–protein interact
  • 西亚试剂:Measuring the evolutionary rate of protein–protein interact
  • Measuring the evolutionary rate of protein–protein interaction Qian, Wenfeng; He, Xionglei; Chan, Edwin; Xu, Huailiang; Zhang, Jianzhi Despite our extensive knowledge about the rate of protein sequence evolution for thousands of genes in hundreds of species,the corresponding rate of protein function evolution is virtually unknown, especially at the genomic scale. This lack of knowledgeis primarily because of the huge diversity in protein f...详细+
  • 西亚试剂:科学家揭示蛋白互作进化速率
  • 西亚试剂:科学家揭示蛋白互作进化速率
  • 5月9日美国密歇根大学与四川大学的研究人员联合在国际著名期刊美国《国家科学院院刊》(PNAS)上发表了题为“Measuring the evolutionary rate of protein–protein interaction”的研究论文。 领导这一研究的是著名华人学者张建之教授。其早年毕业于复旦大学。1998年美国宾西法尼亚州立大学遗传学博士毕业,师从著名的分子进化学家根井正利(...详细+
  • 西亚试剂:Cytosolic DNA Triggers Inflammasome Activation in Keratinoc
  • 西亚试剂:Cytosolic DNA Triggers Inflammasome Activation in Keratinoc
  • Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions Dombrowski, Yvonne; Peric, Mark; Koglin, Sarah; Kammerbauer, Claudia; G??, Christine; Anz, David; Simanski, Maren; Gl?ser, Regine; Harder, Jürgen; Hornung, Veit; Gallo, Richard L.; Ruzicka, Thomas; Besch, Robert; Schauber, Jürgen The proinflammatory cytokine interleukin-1β (IL-1β) plays a central role in the pathogenesis and the course of inf...详细+