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双氯芬酸

别名:双氯芬酸;2-(2,6-二氯苯氨基)苯乙酸;2-[(2,6-二氯苯基)氨基]-苯乙酸 产品编号:286178 CAS号:15307-86-5 分子式:C14H11Cl2NO2 分子量:296.15

订货信息

订货编号 产品名称 规格 包装 价格 数量 操作
A64009-1g 双氯芬酸 ≥98.0% 1g 73.00

A64009-5g 双氯芬酸 ≥98.0% 5g 187.00

A64009-25g 双氯芬酸 ≥98.0% 25g 694.00

A64009-100g 双氯芬酸 ≥98.0% 100g 2434.00

化学性质


属性






描述





产品介绍


Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.




别名


双氯芬酸;2-(2,6-二氯苯氨基)苯乙酸;2-[(2,6-二氯苯基)氨基]-苯乙酸;2-(2,6-Dichloroanilino)phenylacetic Acid




应用


Diclofenac (双氯芬酸) 是COX抑制剂,对绵羊的COX-1和-2的IC50分别为60和220 nM。



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密度 :1.4±0.1 g/cm³

沸点 :412.0±45.0 ℃ at 760 mmHg

熔点 :156-158ºC

分子式 :C14H11Cl₂NO₂

分子量 :296.149

闪点 :203.0±28.7 ℃

精确质量 :295.016693

PSA :49.33000

LogP :4.06

外观性状 :白色至淡黄色结晶粉末

蒸汽压 :0.0±1.0 mmHg at 25℃

折射率 :1.662

危险属性




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包装等级 :III

危险类别 :6.1(b)

海关编码 :2942000000

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