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| 订货编号 | 产品名称 | 规格 | 包装 | 价格 | 操作 |
|---|---|---|---|---|---|
| X495677-x | 利福霉素S | 咨询规格 | 咨询包装 | 咨询价格 |
化学性质
危险属性
质量标准
采购询价
| 熔点 | 179-181°C (dec.) |
|---|---|
| 比旋光度 | D20 +476° (c = 0.1 in methanol) |
| 沸点 | 700.89°C (rough estimate) |
| 密度 | 1.2387 (rough estimate) |
| 折射率 | 1.6630 (estimate) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 苯（微量）、氯仿（微量）、甲醇（微量） |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.85±0.70(Predicted) |
| 颜色 | 橙色至深橙色 |
| 最大波长(λmax) | 390nm(MeOH)(lit.) |
| Merck | 14,8217 |
| InChIKey | BTVYFIMKUHNOBZ-ODRIEIDWSA-N |
1.疏水参数计算参考值（XlogP）:4.1
2.氢键供体数量:4
3.氢键受体数量:12
4.可旋转化学键数量:3
5.互变异构体数量:339
6.拓扑分子极性表面积:195
7.重原子数量:50
8.表面电荷:0
9.复杂度:1480
10.同位素原子数量:0
11.确定原子立构中心数量:9
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:3
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
| RTECS号 | KD1925000 |
|---|---|
| 海关编码 | 2941.90.1050 |
| 毒性 | LD50 in mice (mg/kg): 122 i.v.; 258 i.p.; 3000 orally (Sensi, 1964) |
危险运输编码：
危险品标志：
安全标识：
危险标识：
Gram-positive bacteria
Reactive oxygen species (ROS)
The inhibition of bacterial growth by Rifamycin SV is due to the production of active species of oxygen resulting from the oxidation-reduction cycle of Rifamycin SV in the cells. The aerobic oxidation of Rifamycin SV to Rifamycin S is induced by metal ions, such as Mn 2+ , Cu 2+ , and Co 2+ . The most effective metal ion is Mn 2+ .
Rat liver sub-mitochondrial particles also generated hydroxyl radical in the presence of NADH and Rifamycin S. NADH dehydrogenase (complex I) as the major component involved in the reduction of Rifamycin S. Compared to NADPH, NADH is almost as effective (Rifamycin S) in catalyzing the interactions of these antibiotics with rat liver microsomes. Rifamycin S is shown to be readily reduced to Rifamycin SV, the corresponding hydroquinone by Fe(II). Rifamycin S forms a detectable Fe(II)-(Rifamycin S)3 complex. The Fe:ATP induced lipid peroxidation is completely inhibited by Rifamycin S. Rifamycin S can interact with rat liver microsomes to undergo redox-cycling, with the subsequent production of hydroxyl radicals when iron complexes are present.
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