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尽管近来对于G蛋白偶联受体（GPCR）的结构和功能的理解有了实质性的进展，但许多这些受体的特征依然很少。如今，两篇论文通过使基于配体或结构相似性的GPCR有机化，从而试图解决这一差距。由于一些GPCR配体能够激活不相关的受体（例如，血清素（

DNA methylation in transposons and other DNA repeats is conserved in plants as well as in animals. In Arabidopsis thaliana,

2013年3月23日，北京生命科学研究所何新建实验室在《The EMBO Journal》杂志在线发表题为“The splicing machinery promotes RNA-directed DNA methylation an

Giulia Biffi, David Tannahill, John McCafferty & Shankar Balasubramanian Four-stranded G-quadruplex nucleic acid structur

在生物学领域，最具代表性的形象莫过于DNA的双螺旋结构，它们盘绕成螺旋和超螺旋，形成密实的染色体。然而，在实验室中，人工合成的富含鸟嘌呤（组成DNA的碱基之一，简写为“G”）的DNA链发生折叠，很容易形成一种结构迥异

The unicellular eukaryote Tetrahymena thermophila has seven mating types. Cells can mate only when they recognize cells of

，《PLoS Biology》以封面文章发表了题为“Selecting One of Several Mating Types through Gene Segment Joining and Deletion in Tetrahym

Purification of PCR fragments for cloning After an aliquot of the PCR mixture is analyzed on an agarose gel, the remainder

来自北京大学的研究人员报告称，他们利用一种RNA导向的Cas9核酸酶在哺乳动物细胞和斑马鱼胚胎中有效实现了位点特异性基因编辑。相关论文“Genome editing with RNA-guided Cas9 nuclease in Z

Mesenchymal stem cells (MSC) preferentially migrate to damaged tissues and, due to their immunomodulatory and trophic prope